First, the GS picked bass might have to be changed to the GM
picked or fingered bass. It might not be automatic.
Fretless bass shouldn't be a problem. An overdrive
guitar playing high note lead should be changed to GM distortion
guitar, which is louder. Vocal, choir leads should be made
into GM accordian, or again something brassier and louder in
order to be heard. There's nothing much you can do with the
drums.
They're just going to be muffled and mushy.
And if the rhythm is a driving distortion guitar, it
may be difficult to find a GM substitute. In some cases, a
bass & lead, or cello, or sawtooth, or something 'buzzy'
might work, in others, it might need to be transposed up an
octave, in others, just selecting the fingered bass (maybe
a contrabass) might
quiet it down if need be, particularly if it has a lot of
low notes one wants to keep as is.
Or even the overdrive guitar might do the trick, here;
though you can't just as a rule swap overdrive for distortion
and vice versa.
Then again, for the rhythm guitar, there may be nothing satisfactory.
[And just one last thing.
If you use the little Voyetra mixer, if it's still shipping with
various cards, be careful that you don't e-mail or send off
your version after re-mixing.
Old versions of this mixer,
even perhaps current versions, liked to strip off
text, copyright, and all sorts of identifying information
in MIDI files, as soon as you saved it to disk.
Better to get a sequencer (the Winjammer shareware is,
I believe, still only $50).]